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TMAO is known to promote endothelial dysfunction, oxidative stress, and hypertension, thereby exacerbating the pathophysiological cascade of PE [93,94,95,96,97]

Hypoxia-Inducible Factor (HIF) Pathway Hypoxia leads to the stabilization of HIF-1 among hypoxia-inducible factors which then activates genes that help cells adapt metabolically by upregulating glutamine transporter proteins

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Hall, 2008

Modulation of the activities of UPS and ALS may contribute to the treatment of ccRCC