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GBB is a pro-atherogenic intermediate in the conversion of L-carnitine to TMAO controlled by the gut microbiota (Koeth et al., 2014)

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This single-arm clinical trial is an exploratory study to determine the effectiveness of a two-week dietary glycine supplementation in correcting its deficiency in individuals with severe obesity and to evaluate its impact on the metabolic pathways that are dependent on glycine availability, including the glycine conjugation detoxification pathway, GSH synthesis, and the 1-carbon cycle