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Therefore, modifying or interfering with macrophage polarization or their switch from an M2 to an M1 phenotype remains an attractive strategy to potentiate the effector immune response

They are implicated in cell-to-cell interactions, cellextracellular matrix interactions, receptor crosslinking or lattice formation, intracellular signaling, and posttranscriptional splicing (90)

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[DOI] [PubMed] [Google Scholar] 112.Ridderikhof M.L., Leenders N., Goddijn H., Schep N.W., Lirk P., Goslings J.C., Hollman M.W