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The first demonstration of the ability of efgartigimod to reduce systemic IgG levels in humans was published in 2018 [224]

doi: 10.1007/s12020-022-03191-9 35 XiongRGZhouDDWuSXHuangSYSaimaitiAYangZJet al

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In summary, HCC is associated with a significant restructuring of the gut mycobiota, characterized by an expansion of Ascomycota , Candida , and Malassezia at the expense of beneficial fungi such as Saccharomyces , suggesting that fungal dysbiosis may be implicated in HCC pathogenesis