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Nutrients 12:910

Acknowledgements This study was supported by Suzhou Municipal Key Core Technology Research Projects (2023SS19) and Youth Excellence Projects of CNNC (CNNC-2020)

The combination of vancomycin, neomycin sulfate, metronidazole, ampicillin, and other broad-spectrum antibiotics can alleviate choline-induced atherosclerosis in mice, and the mechanism may be related to the inhibition of choline conversion to TMA, the reduction of TMAO levels, and the inhibition of macrophage foaming

The potential of TMAO to result in atherogenic effects is linked to alterations in cholesterol and bile acid metabolism, inflammatory pathway activation, and foam cell formation promotion

[DOI] [PubMed] [Google Scholar] 36.Pallardo FV, Lloret A, Lebel M, d'Ischia M, Cogger VC, Le Couteur DG, et al

Valproate-induced hyperammonaemic encephalopathy In chronic VPA dosing hyperammonaemia occurs in nearly 50% of patients, but this remains asymptomatic in almost 50% of cases [39]