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doi: 10.3389/fendo.2025.1653975 Received 25 June 2025 Accepted 04 August 2025 Published 25 August 2025 Volume 16 - 2025 Edited by Mohammad Ishraq Zafar, Zhejiang University, China Reviewed by Andrea Delbarba, Asst degli Spedali Civili di Brescia, Italy Ibrahim Mehmet Tulu, Manisa Celal Bayar University, Trkiye Updates Copyright 2025 Zhang, Tong, Jin and Sun

Eur J Med Chem 98:203211 Iqbal J, El-Gamal MI, Ejaz SA, Lecka J, Sevigny J, Ohg CH (2018) Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies

However, the similarity in erythrocyte 2,3-DPG levels in patients with Alzheimers disease with or without dementia argues against this hypothesis and implies that oxygen-regulatory pathways do not participate in brain hypoxia (Reference Jremo, Jejcic and Jelic140)

Furthermore, dithiol gliotoxin can also be oxidized into gliotoxin by cellular O 2 in turn, thereby resulting in the accumulation of ROS via the redox-uptake system mediated by gliotoxin