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[0266] In certain embodiments "conservative amino acid substitutions" in the sequences of the anti-ALPP/ALPPL2 antibodies described herein, i.e., nucleotide and amino acid sequence modifications that do not abrogate the binding of the antibody encoded by the nucleotide sequence or containing the amino acid sequence, to the antigen, e.g., ALPP/ALPPL2 are contemplated

Am J Gastroenterol 97:18431844 Centers for Disease Control and Prevention (2003) Trends in AgingUnited States and worldwide

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