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PMID 8616884

Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men

Provencher, A.-M

It can be hereditary germline change or acquired during early developmental stage, affecting structures of embryonic ectoderm, where in, there is mutation or rarely somatic mosaicsism(RASopathy) of NF1 gene or its alleles, present on Chromosome 17 and is responsible for synthesis of protein neurofibromin which regulates cell proloferation and differentiation which hampers tumour suppressor activity giving rise to tumours of nervous system

This design concept aligns closely with recent reports of multifunctional nanosystems developed for tumor and immunotherapy applications

Furthermore, screening of several FDA-approved compounds using a luciferase reporter assay on human astroglial cells identified harmine, a beta-carboline alkaloid, as a potent EAAT2 promoter