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Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology

10.1055/s-2008-1034321 71 TalebM.AbdeltawabN.ShammaR.AbdelgayedS.MohamedS.FaragM.et al (2018)

The dried metabolites were reconstituted in 60% acetonitrile followed by overtaxing for 30 s and then centrifugation for 30 min at 20,000 g at 4 C

Sarkar R, Chugh S, Garg VK

To put that in perspective, thats about the size of the annual budget for the state of Delaware