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LDN also quiets overactive immune cells in the brain and spinal cord (called microglia) that drive inflammatory responses in conditions related to immune system and persistent pain think of it as finally silencing a car alarm that's been going off for months

Research conducted by Cui demonstrated that HEP-1, derived from HEFB, can augment the relative abundance of beneficial genera such as Akkermansiella , Dunaliella , and Lactobacillus , thereby modulating the composition and abundance of intestinal microorganisms to sustain the homeostasis of the gut microbiome [52]

10.1038/cr.2017.133 190 ZhaoC.SunG.LiY.KongK.LiX.KanT.et al (2023)