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39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections

Furthermore, mechanisms of OIPN can reinforce each other, and combination therapies may be required for effective management

For humans, the World Health Organization 2020 guidelines recommended that all adults should undertake 150300 min of moderate-intensity or 75150 min of vigorous-intensity physical activity, or an equivalent combination of both moderate- and vigorous-intensity aerobic physical activity per week

A 2018 meta-analysis of 132,738 mother-child pairs found associations that increased with longer exposure duration

Requires good side-effect management

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