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These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses

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Glucagon is usually thought of as a glucose- raising hormone, but in the context of simultaneous GLP-1/GIP agonism the net effect studied in trials was increased energy expenditure alongside strong glycemic control a combination that appears to explain the outsized weight effect observed in the research