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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

Bested K, Jensen LM, Andresen T, Tarp G, Skovbjerg L, Johansen TSD, Schmedes AV, Storgaard IK, Madsen JS, Werner MU, Bendiksen A (2023) Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study

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Thus, research should be expanded further to include studies on chronic fatigue states humans, before considering polyphenols for clinical use in patients with CFS

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