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disease-induced permeability), and cellular (cell entry and endosomal escape)

For example, the presence of tumor low oxygen (hypoxia) environment results in the stabilization and activation of hypoxia inducible factors (HIFs), which regulate the transcription of target genes and consequently modulate lipid metabolism (Metallo et al., 2011)

The nerves do not have enough room to function correctly and they begin to cause pain, numbness and weakness

10.1016/j.cell.2012.03.042 39 DollS.FreitasF

[DOI] [PubMed] [Google Scholar] Huang JP, Hsu SC, Li DE, Chen KH, Kuo CY, Hung LM

Organic methylmercury intoxication results in substantial neuronal depletion and gliosis in the calcarine and parietal cortices of the brain and cerebellar folia, as was demonstrated in patients presenting with classic Minamata disease