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A seminal study from Muller and colleagues demonstrated that high salt treatment depleted Lactobacillus murinus from the gut microbiota, resulting in an increase in TH 17 cells and salt-sensitive hypertension, findings that were replicated in a pilot study in humans [17]

Cytokines and inflammatory markers, including tumor necrosis factor-alpha (TNF-) and interleukins 1 or 6 (IL-1, IL-6), further indicate the level of hepatocyte-macrophage apoptosis (Hu et al., 2025)

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