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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12

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However, in clinical wellness settings, different peptides are often associated with different goals, depending on how they influence recovery, metabolism, or growth-hormone pathways