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Methods A total of 147 women with PCOS were randomly assigned into two groups: the combo group ( n = 72) received a combination of metformin, pioglitazone, and ALC (500 mg, 15 mg, and 1500 mg, respectively), twice daily

3 NASH is associated with increased risks of fibrosis, cirrhosis, liver failure, and liver cancer

Kidney-Related Disease Chronic kidney disease is a gradual loss of kidney function that leads to the accumulation of waste products in the blood

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Lipid signaling is involved specifically in DA mesolimbic transmission [95], by regulating reinforcing and motivational aspects of feeding [96], but also VTA DA neurons firing [97, 98]