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[38,39] Geroprotective effect of Metformin has been reported in multiple animal models including lifespan extension in Caenorhabditis elegans , Drosophila melanogaster and mice, and deceleration of aging clocks in male nonhuman primates

These extreme plasma oxalate levels are only exceeded by those in PH patients with levels of 80125 mol/L commonly found [110, 111]

Furthermore, epigenetic changes, specifically in miRNA levels in the hippocampus and prefrontal cortex in rats following jet fuel exposure, provide additional support for neurologic effects that may impact memory, attention, and different characteristics of executive functioning

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Protein deglycase DJ-1, functions as a redox sensor with peroxiredoxin-like activity protecting neurons against oxidative stress [153,154]