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Despite similar degrees of ATP depletion, pyroglutamate increased more in cystinotic fibroblasts than in controls, while GSH decreased to lower levels

The obtained results demonstrate a high efficiency of epithalamin therapy for prophylaxis of age-related pathology, including cancer, showing a new physiological way to slow down pathological processes and to extend human life spans

Availability of data and materials The data generated and analyzed during this study are available from the corresponding author on reasonable request

Mitochondrial function declines as worms age (15)

After treatment with noopept (10 M) for 72 h followed by 2535 (5 M) for 24 h, cells were incubated with 200 l MTT solution (0.5 mg/ml) at 37C for additional 4 h

202 RaiM