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C., Bisordi C., et al., Amyotrophic Lateral Sclerosis and Oxidative Stress: A DoubleBlind Therapeutic Trial After Curcumin Supplementation, CNS & Neurological Disorders Drug Targets 17, no

These microglia release various pro-inflammatory factors, which further disrupt iron balance, creating a detrimental feedback loop

Together, these factors determine whether necroptotic signaling leads to effective antitumor immunity or chronic inflammation that supports tumor progression (20, 48, 49)

They can be divided into many subgroups, including flavones, isoflavones, lignans, stilbenoids, tannins, and curcuminoids, some examples of which are shown in Fig

Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, et al

Jain N, Jabbour E, Konopleva M, Pemmaraju N, Thompson P, Short N, Kadia T, Borthakur G , Daver N, DiNardo C, Aldoss I, Cook R, Ravandi F, Kantarjian H
