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In other cases, the patient may simply begin to quickly experience myriad benefits of NAD+ therapy

The complexity and heterogeneity of complex I disorders can be emphasized by the constellation of disorders termed MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes

therefore, the rate of cholesterol efflux is still critical to understanding RCT and HDL function

Zhou et al., 2024) (Table 1)

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Abbreviations ROS: Reactive oxygen species CNS: Central nervous system AD: Alzheimers disease PD: Parkinson's Disease HD: Huntington's disease ALS: Amyotrophic lateral sclerosis Nrf2: Nuclear factor erythroid 2related factor 2 Keap 1: Kelch-like ECH-associated protein 1 CNS: Central nervous system bZIP: Basic leucine zipper ARE: Antioxidant response elements HO-1: Heme oxygenase-1 NQO1: NAD(P)H quinone dehydrogenase 1 PI3K: Phosphoinositide 3-kinase MAPK: Mitogen-activated protein kinases NF-B: Nuclear factor-kappa B PKC: Protein kinase C NSC: Neural stem cell LTP: Long-term potentiation MRP: Multidrug resistance-associated proteins A: Amyloid beta mHTT: Mutant huntingtin MDD: Major depressive disorder GCL: Glutamate cysteine ligase CUMS: Chronic unpredictable mild stress PTSD: Post-traumatic stress disorder BBB: Blood-brain barrier DMF: Dimethyl fumarate MS: Multiple sclerosis AAV: Adeno-associated virus 6-OHDA: 6-Hydroxydopamine GSH: Glutathione CAT: Catalse GSK: Glycogen synthase kinase References Di Domenico F, Lanzillotta C, Perluigi M (2024) Redox imbalance and metabolic defects in the context of Alzheimer disease