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Identity Appearance White lyophilized powder Molecular Formula C78H123N23O23S2 Molecular Weight 1,815.06 g/mol CAS Number 221231-10-3 Sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge) Synonyms hGH fragment 177-191 Purity 99% Storage profile Storage (Lyophilized) -20C (long-term), 2-8C up to 30 days (short-term) Storage (Reconstituted) 2-8C Shelf Life (Lyophilized) 24 months at -20C Shelf Life (Reconstituted) Up to 28 days at 2-8C Reconstitution Bacteriostatic water (0.9% benzyl alcohol) for research reconstitution Handling Protect from direct light
Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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Tracking calories can help prevent overeating and make it easier to reach goals

used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies
