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One four amino-acid chain appeared to govern the results seen in rats Ala-Glu-Asp-Gly

2.2 Dysregulation of neurotrophic support Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), constitute a signaling axis fundamental to neuronal survival, differentiation, and synaptic plasticity within the central nervous system (Numakawa and Kajihara, 2025)

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24 In addition, a number of powerful preformed inflammatory mediators are released, including cytokines (IL-4, IL-5, IL-6, IL-13, TNF- ) and chemokines (eg CXCL1 and CCL2), histamine, serglycin proteoglycans, and several mast cells-specific proteases (chymases, tryptases, and carboxypeptidase A

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