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A key mediator of Treg suppression is the surface receptor CTLA-4 which is constitutively expressed on nTregs

Degnan, P
Waghray M, Cui Z, Horowitz JC et al (2005) Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

Sex differences in hypertension: where we have been and where we are going

Zhonghua Chuang Shang Za Zhi

The inflammation depends also on the impaired energy metabolism at the level of the mitochondria, which causes the activation of the microglia and the relative production of a plethora of pro-inflammatory mediators, including prostaglandins, cytokines, chemokines, complement, proteinases, reactive species of oxygen (ROS), and reactive species of nitrogen (RNS) [23,24]
