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High molecular weight coffee melanoidins are inhibitors for matrix metalloproteases

Conclusions Our study suggests that Si incorporated into RP matrix was able to counterbalance, more efficiently than HxT, the deleterious effect of consuming a high-saturated/high-cholesterol diet, by improving the liver antioxidant defenses in the context of NASH.

Then, a fermentation experiment in Erlenmeyer flasks was performed using the G3-SF strain (containing ScGSH1, ScGSH2, StGshF, and ScADK1), with the highest GSH titer and yield of 999.3347.26 mg/L and 91.534.70 mg/g, respectively

Can support enhanced detoxification

Interestingly, the chronological life span (CLS) was lowered in the gsh1 strain cultured with 10% glucose but not under dietary restriction