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In one embodiment, the oligonucleotide comprises a sequence of N 1 N 2 CGN 3 CG(T) x GN 4 CGN 5 T, or a stereoisomer, a mixture of two or more diastereomers, a tautomer, or a mixture of two or more tautomers thereof

Hence, this impaired HSP production (302) combined with oxidative and nitrosative stress, and low-grade inflammation could explain the exercise intolerance and muscle dysfunction seen in ME/CFS patients (303, 304)

Arnold J

Lack of correlation between non-labile iron parameters, total carbonyl and malondialdehyde in major thalassemia

Identifying these mechanisms may lead to development of therapies directed at either preventing or correcting these abnormalities

The epidemiologic data relating to the association of ALDH2 deficiency and cancer risk are striking: ALDH2 homozygotes who are moderate-to-heavy consumers of ethanol have a 712-fold increased risk for esophageal cancer, making ALDH2 deficiency the most common hereditary disorder associated with an increased cancer risk