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Involvement of GSH in pathological conditions has been reported for many diseases [10, 11, 12, 13]

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The highest intracellular concentration of GSH was 186.77 mg/L produced by strain W303-1b/F, and most of the synthesized GSH could be attributed to the function of the introduced GshF as strain W303-1b/gsh1/F yielded a similar amount (about 90 %) GSH to W303-1b/F

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While glutamate is typically abundant in the standard human diet, cysteine and glycine are frequently depleted, especially during times of chronic metabolic stress, severe viral infection, or the natural aging process