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Likewise, caffeic acid itself directly inhibited ERK1/2 (MAPK) activity in melanoma and epidermoid carcinoma cells, disrupting a key pathway that promotes tumor growth and migration (150)

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Another mechanism by which KD affects mitochondria is by increasing the expression of uncoupling proteins (UCPs) [40], which are located in the inner mitochondrial membrane

doi:10.1016/j.cps.2016.03.004 7