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Essentially, the lack of modern data proving it doesnt happen is the reason for the restriction

[DOI] [PubMed] [Google Scholar] 66.Vos TJ, Caracoti A, Che JL, et al

Center for Medicine in the Public Interest
Quadrelli, S., Mountford, C

HSF Biotech company uses SoliPro Micro-encapsulated Solid Technology is a process where small solid particles are coated with a protective layer

This approach is more common in research settings than clinical practice, but some providers believe it optimizes the balance between efficacy and side effects by tailoring the dose to individual body size
