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Tumor cells overexpressing HER2 show marked increases in lactate dehydrogenase-A (LDHA) resulting in high intra-tumor lactate production to sustain glycolysis and cancer cell growth [45, 46]

The clinical correlation observed between PKM2, lactate and HMGB1 levels forms a metabolic inflammatory feedback loop in the pathogenesis of sepsis

Studies have shown that using selenium as a kidney support supplement protects the kidneys from ischemic injuries, which occur when the kidneys are deprived of sufficient oxygen

doi: 10.1002/cyto.10133

doi: 10.3389/fnins.2015.00372 100 MurphyM

These events underscore the potential molecular crosstalk between both pathways, offering a fascinating opportunity to investigate novel therapeutic strategies targeting both pathways, which may enhance treatment efficacy
