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Since peptide helicity is essential for their biological functions, the incorporation of DMSO poses a critical limitation in characterizing peptide drugs

Based on the in vivo experiment in the ICV-STZ rat model of AD, modulation of the PI3K/Akt/GSK3 signaling pathway could diminish oxidative stress, neuro-inflammation, and apoptosis, Moreover, amyloid plaque number and phosphorylated tau expression were marked decrement (Nishizaki, 2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Robinson EB, Neale BM, Hyman SE

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