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Based on this, one of the directions is associated with the development of drugs that block the synthesis of GSH and thioredoxin in tumor cells [41]

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Primarily, it is known that metformin can induce autophagy as a protective response against cellular stress, and numerous studies have reported that this drug enhances autophagy, thereby affecting various cancer types including gliomas

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Therefore, patients may require supplements for their whole life to meet the bodys demands for B12