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Xu, S., Zhang, H., Yang, X., Qian, Y
Beyond trying to bind tau, companies are thinking about cell-penetrating methods to block production of the protein at its source
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DevosDLebouvierTLardeuxBBiraudMRouaudTPoucletHet al
Because NNMT activity intersects methyl donor utilization and nicotinamide handling, experimental inhibition can be used to probe pathway level relationships among methyl economy balance, NAD+ salvage flux, and downstream metabolic signaling in a range of preclinical systems
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