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Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (Me/Cfs)

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Quality of included reports was scored using the Jadad composite scale,13 which assesses the description of randomization, blinding, and withdrawals in the reports.14 The quality scale ranges from 0 to 5 points with a low quality report of score 2 or less and a high quality report of score at least 3.15 All discrepancies were resolved after going back to the original source papers, by consensus and involvement of a third reviewer when necessary

According to the studies presented above, chemotherapy may induce apoptosis of progenitor cells leading to reduced differentiation to megakaryocytes and platelets, while upstream HSCs can supplement progenitors by self-renewal and differentiation into downstream progenitors

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