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In order to prevent this scenario, cells utilize phase II detoxification enzymes

As a result, MET may be pivotal in the initial development of a tumour, as well as in its progression and ability to persist through cytotoxic treatment

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These shifts from the third or fourth line of care to the earlier stages of cancer care, now including first or second-line settings, are because they are very potent in chemotherapy without significant systemic side effects (219)