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Tesfamariam K, De Boevre M, Kolsteren P, Belachew T, Mesfin A, De Saeger S, et al

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[369] demonstrated that somatic hypermutation rates are similar in both young and elderly individuals, suggesting that the increased number of mutations in Ig genes seen in older adults [370] likely results from cumulative exposure over time rather than an inherently altered mutation process

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