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thus, thorough preclinical validation is essential

The safety profile supports consistent long-term daily use, and the collagen-stimulating effects are cumulative, meaning uninterrupted use produces better results than starting and stopping

doi: 10.1186/1479-5876-9-171

In response to oxidative challenges, Nrf2 dissociates from its inhibitor, Kelch-like ECH-associated protein 1 (Keap1), moves to the nucleus, and binds to the antioxidant response element (ARE) to activate the Nrf2-dependent antioxidant system

A routine dosage ranges from 500-2,000 mcg 1-3 times weekly