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67 WangC

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doi: 10.1111/j.1567-1364.2010.00687.x 103 LiuH.ZhaoX.WangF.LiY.JiangX.YeM.et al

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doi: 10.1016/j.molimm.2014.03.005 205

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However, it is not immediately available to the systemic circulation

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doi: 10.1158/2326-6066.cir-21-0459 2 WangYRenYZhangQYiPChengC

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As a matter of fact, silymarin, a complex of flavonolignans from the fruit Sylibum marianum , has shown in preclinical test to inhibit cholesterol acyltransferase and HMGCoA reductase activity and improve LDLC uptake by the liver, definitely reducing cholesterol absorption and lipoprotein biosynthesis (Skottov & Krecman, 1998

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