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There are four different methods namely dose by factor, similar drug, pharmacokinetically guided, and comparative approaches are described in literature to assess the initial dose.[1] The dose by factor method is an empirical approach and use the no observed adverse effect levels (NOAEL) of drug from preclinical toxicological studies to estimate human equivalent dose (HED).[2] Here, the dose selection is based on minimum risk of toxicity, instead of choosing one with minimum pharmacologic activity in humans

This finding might be related to excessive daytime sleepiness in narcolepsy

In a classic study by White in 1895, 111 men with bladder outlet obstruction were castrated 60

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The role of hydrogen peroxide in regulation of plant metabolism and cellular signalling in response to environmental stresses