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Rapid injection: Delivering the solution quickly deposits a concentrated volume of the compound into a small area of tissue all at once, giving the surrounding tissue less time to equilibrate with the pH shift

Muscle contractility dysfunction precedes the loss of motor unit connectivity in the SOD1 G93A mouse model of ALS (Wier et al., 2019) with neurodegeneration being one of the determinant risk factors for muscle quality (Di Pietro et al., 2017

Metals increase GSH oxidation and PC production, resulting in a depletion of cellular GSH levels and consequently, the feedback inhibition is released (Figure 1: GSH biosynthesis) [38,39]

doi:10.1186/s40200-016-0250-x

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To further investigate whether P-Mn/TI@mHSA treatment could affect the sensitivity of bone marrow-derived macrophages (BMDMs) to inflammatory stimulation, BMDMs were isolated from the tibia of C57BL/6 mice (Supplementary Figs