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The generation of viral particles and reconstitution of cancer cell lines with different ANKIB1 mutants or TLR3-moTAP were performed as described previously 10

All these changes lead to cytokine storm characterized by increased expression and release of proinflammatory cytokines that participate in the pathogenesis of ARDS during virus respiratory infections like COVID-19

doi: 10.1038/s41580-021-00418-x 125 JainS

1 H NMR (400 MHz, Chloroform-d) = 8.65 (dd, J = 4.8, 2.6 Hz, 1H), 8.047.93 (m, 2H), 7.83 (td, J = 7.7, 2.2 Hz, 1H), 7.74 (dd, J = 8.1, 2.6 Hz, 1H), 7.32 (p, J = 3.3 Hz, 1H), 7.026.91 (m, 2H), 4.15 (dt, J = 8.6, 3.9 Hz, 2H), 3.83 (dt, J = 8.5, 3.7 Hz, 2H), 2.03 (dt, J = 8.4, 3.9 Hz, 2H)

Chen M.-C

It also provides a new dimension to understanding immunopharmacology and immunotoxicology, with huge potential to impact disease etiology and pathogenesis, and for the development of novel and personalized therapeutics