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Further, decrease in levels of B 12 demonstrated in patient with multiple sclerosis (Miller et al., 2005)

For GSH, the ratio was assumed to be 1:1, as there are currently no studies demonstrating a bulk tissue dependence for MRS-measured GSH

doi: 10.1016/S0140-6736(23)01419-8 5 BurchillE.WatsonC

A study highlighted S100A1s ability to restore calcium cycling in cardiomyocytes, improving contractility in heart failure models, and gene therapy using AAV-S100A1 showed reduced fibrosis and hypertrophy in rodents (Rostami et al., 2025)

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Distinguish biomarkers from outcomes : Recognize that biomarker-based health monitoring can signal exploratory trends but does not always prove hard clinical outcomes