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1996;271(5 Pt 1):C142437

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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)

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Another potential therapeutic target is the kinase CDK8, which, as a Mediator subunit, is often amplified in and is required for -catenin-dependent transcription and proliferation of colon cancer cells (Firestein et al., 2008