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As discussed previously, RIDD represents a highly conserved function of IRE1 in cellular homeostasis 64

*Correspondence: Maria Teresa Baltazar, [email protected] Present address: Danilo Basili, Socit des Produits Nestl S.A., Nestl Research, Lausanne, Switzerland Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The significance of PPAR as a diabetes target is apparent not only from the observed effects of drugs that activate the receptor but also from genome wide screens showing that mutations in the PPAR gene are correlated to familial insulin resistance

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