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It remains an experimental compound used in research and wellness settings, particularly in anti-aging clinics and weight management programs

While there is no corroborative clinical trial data, animal experiments suggest that hydroxocobalamin produces a time and organdependent, selective regulation of nitric oxide synthases during endotoxemia and regulates downstream inflammatory mediators, thereby having a potential role in the treatment septic shock 4

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In preclinical models of neuropathic pain, ARA 290 demonstrated beneficial effects that include IRR-dependent prevention of the development of allodynia in a peripheral nerve transection model (15) or in an inflammatory neuritis model (16), as well as attenuation of spinal cord inflammation (15)