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These PUFAs are different from omega-6 PUFAs like arachidonic acid and play important roles in tumour microenvironment through competitive integration into cell membranes and in enzymatic metabolism through the cyclooxygenase-2 (COX-2) or lipoxygenase pathways

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Accumulating evidence shows that mutated OCTN1 is associated with susceptibility to Crohn's disease [42, 44]

In cultured pulmonary endothelial cells in vitro, carnitine can effectively reduce the apoptosis, damage to migration and obstruction of angiogenesis caused by hyperoxia, resulting in improvements in endothelial cell dysfunction and persistent lung injury under hyperoxic conditions [308]

Recently, massive studies pay more attention to atherogenic LDL and anti-atherogenic HDL, which are associated with cardiovascular disease risk and antagonistic effects in atherosclerotic development 8,9