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Preclinical studies have indicated that both peptides are safe within recommended doses
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New studies are still coming out, though, so take a look at new findings as they appear

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Phenotypic heterogeneity within bacterial populations has also been demonstrated as a factor that can contribute to resistance, where QS-deficient cheater cells exploit QS-dependent public goods, such as virulence factors, without contributing to signal production, thereby reducing the selective pressure imposed by QSIs [220]

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