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19, 73 It is not known whether those muscular abnormalities are usually primary pain generators (giving rise to associated secondary bladder pain) or are themselves secondary phenomena elicited by the primary bladder pain of IC/BPS

They peak at 72-96 hours and can last for 14 days or longer

By restoring B12 levels, many individuals experience improved mood, reduced feelings of anxiety or depression, and enhanced mental clarity

Given its critical importance, vitamin B9 deficiency is associated with severe neurological complications, such as spinal cord and peripheral nerve disease, dementia, organic brain syndrome, and pyramidal tract damage (, , )

Its mechanism of action is due to the fact that it assists with maintenance of intestinal mucosal integrity, modulation of inflammatory response, nucleotide biosynthesis, energy metabolism, and stimulation of immunity (Perna et al., 2018)