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(d) On the axial ADC map, the lesion shows a low signal peripherally and a high signal centrally, in keeping with central cyst formation, which is often seen in long-standing (ancient) schwannomas Fig

In addition, endothelial cell activation leads to increased production of reactive oxygen species (25) that can cause oxidative modification of apoB-containing lipoproteins (26)

So, while 4-6 weeks is a good number to keep in mind for the reconstituted solution, the real story is in the details