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The primary role of the BBB is to control the flow of substances between the blood and the central nervous system according to the physiological needs of the brain

10.7759/cureus.76265 137 PunziL.ScagnellatoL.GalozziP.BaggioC.DamascoA.OlivieroF.et al (2025)

To activate efficient T cell immunity, a moderate level of ROS is needed, however, excessive ROS would cause toxicity to the T cells, because the improper level leads to the formation and maintenance of an immunosuppressive tumor microenvironment

DM and its complications are significantly influenced by ROS

This triggers protein kinase A (PKA), initiating intracellular signaling

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